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Case Studies & Documentation

While cryotherapy is rather new in the United States, several studies have been published that show the benefits of Cryotherapy in many conditions.  The below covers the following conditions where studies have been proven.  

Spine Diseases Treated by Whole Body Cryotherapy .  Armand Cholewka, Zofia Drzazga, Aleksander Sieron´ and Agata Stane

A single exposure to Whole Body Cryotherapy significantly decreases inflammation after strenuous exercise and may accelerate recovery and reduce exercise induced muscle damage.
Time-Course of Changes in Inflammatory Response after Whole-Body Cryotherapy Multi Exposures following Severe Exercise. Herve Pournot, Francois Bieuzen, Julien Louis, Jean-Robert Fillard, Etienne Barbiche, Christophe Hausswirth. Research Department, National Institute of Sport, Expertise and Performance (INSEP), Paris, France.

A single Whole Body Cryotherapy session before exercise seemed to have beneficial effect on the antioxidant and anti-inflammatory markers when compared with control.
The Effect of Submaximal Exercise Preceded by Single Whole-Body Cryotherapy on the Markers of Oxidative Stress and Inflammation in Blood of Volleyball Players. Celestyna Mila-Kierzenkowska, Alicja Jurecka, Alina Wozniak, Michal Szpinda, Beata Augustynska, and Bartosz Womiak. Oxidative Medicine and Cellular Longevity Volume 2013, Article ID 409567, Page 10.

Three Whole Body Cryotherapy sessions within 48 hours after damaging running exercises accelerate recovery from exercise-induced muscle damage to a greater extent than from passive modalities or far-infrared modalities.
Effects of Whole-Body Cryotherapy vs. Far-Infrared vs. Passive Modalities on Recovery from Exercise-Induced Muscle Damage in Highly Trained Runners. Christophe Hausswirth, Julien Louis, Francois Bieuzen, Herve Pournot, JeanFournier, Jean-Robert Filliard, Jeanick Brisswalter. Research Department, National Institute of Sport, Expertise and Performance (INSEP), Paris, France.

Whole Body Cryotherapy caused a decrease in pro-inflammatory (bad) interleukins (ILs) and rise in anti- inflammatory (good) ILs. By contrast, ice application has been shown to increase pro- inflammatory ILs by as much as 29% (8, ref in article). (Ref 49 in article). Norepinephrine responded positively to Whole Body Cryotherapy (3x/wk) and may play a role in pain relief effect. (Ref 60, in article).

Time-Course of Changes in Inflammatory Response after Whole-Body Cryotherapy Multi Exposures following Severe Exercise. Herve Poumot, Francois Bieuzen, Julien Louis, Jean-Robert Fillard, Etienne Barbiche, Christophe Hausswirth. National Institute of Sports, Expertise and Performance, Paris, France.

A study of rheumatoid arthritis patients reported the one variable that showed definite improvement with Whole Body Cryotherapy (vs local cold treatment) was pain. Patients report less pain following Whole Body Cryotherapy.
Effectiveness of different cryotherapies on pain and disease activity in active rheumatoid arthritis. A randomized single blinded controlled trial. H.E. Hiroven, M.K. Mikkelsson, H. Kautiaine, T.H. Pojolainen, M. Leirisalo-Repo. Clinical and Experimental Rheumatology 2006; 24:295-301.

Effects of whole body cryotherapy on multiple sclerosis patients was positive (and postulated to be) beneficial. The total antioxidative state is distinctly reduced in MS patients vs. healthy population. The Whole Body Cryotherapy proved beneficial in treatment of MS patients and better than exercise alone.
Effects of the whole-body cryotherapy on a total anti-oxidative status and activities of some antioxidative enzymes in blood of patients with multiple sclerosis – preliminary study. Elizabeth Miller, Malgorzata Mrowicka, Katarzyna Malinowska, Krystian Zolynski, and JozefKedziora. The Journal of Medical Investigation 2010; 57:168-173.

Whole Body Cryotherapy is used widely in many applications, especially degenerative and inflammatory joint diseases and fibromyalgia.
(Ref. 2 Sieron A, Cieslar G. The application of cold in medicine – cryosurgery and cryotherapy. Bielsko-Biala Poland:a-Meica Press; 2003 (in Polish)). Thermovision diagnostics in chosen spine disease treated by whole body cryotherapy. Armand Cholewka, Zofia Drzazga, Aleksander Sieron, and Agata Stanek. J Therm Anal Calorim 2010; 102:113-119.

Study of a small sample suggests positive effects on treatment of depressive and anxiety disorders. It is postulated/suspected that the pain relief associated with Whole Body Cryotherapy and that commonly accompany emotional disorders may be responsible for the perceived benefits.
Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders. Joanna Rymaszewka, David Ramsey and Sylwia Chladzinska-Kiejna. Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland. Arch lmmunol. Ther. Exp., 2008; 56:63-68.

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